Bronchial Wall Measurements in Patients after Lung Transplantation: Evaluation of the Diagnostic Value for the Diagnosis of Bronchiolitis Obliterans Syndrome

Sabine Dettmer, Lars Peters, Claudia de Wall, Cornelia Schaefer-Prokop, Michael Schmidt, Gregor Warnecke, Jens Gottlieb, Frank Wacker and Hoen-oh Shin

PLOS ONE, 2014, vol. 9, issue 4, 1-13

Abstract: Objectives: To prospectively evaluate quantitative airway wall measurements of thin-section CT for the diagnosis of Bronchiolitis Obliterans Syndrome (BOS) following lung transplantation. Materials and Methods: In 141 CT examinations, bronchial wall thickness (WT), the wall area percentage (WA%) calculated as the ratio of the bronchial wall area and the total area (sum of bronchial wall area and bronchial lumen area) and the difference of the WT on inspiration and expiration (WTdiff) were automatically measured in different bronchial generations. The measurements were correlated with the lung function parameters. WT and WA% in CT examinations of patients with (n = 25) and without (n = 116) BOS, were compared using the unpaired t-test and univariate analysis of variance, while also considering the differing lung volumes. Results: Measurements could be performed in 2,978 bronchial generations. WT, WA%, and WTdiff did not correlate with the lung function parameters (r

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0093783

DOI: 10.1371/journal.pone.0093783

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