Pallidal Index as Biomarker of Manganese Brain Accumulation and Associated with Manganese Levels in Blood: A Meta-Analysis

Shao-Jun Li, Li Jiang, Xue Fu, Shuang Huang, Yan-Ni Huang, Xiang-Rong Li, Jing-Wen Chen, Yong Li, Hai-Lan Luo, Fang Wang, Shi-Yan Ou and Yue-Ming Jiang

PLOS ONE, 2014, vol. 9, issue 4, 1-7

Abstract: Objective: The current study was designed to evaluate the sensitivity, feasibility, and effectiveness of the pallidal index (PI) serving as a biomarker of brain manganese (Mn) accumulation, which would be used as an early diagnosis criteria for Mn neurotoxicity. Methods: The weighted mean difference (WMD) of the PI between control and Mn-exposed groups was estimated by using a random-effects or fixed-effects meta-analysis with 95% confidence interval (CI) performed by STATA software version 12.1. Moreover, the R package “metacor” was used to estimate correlation coefficients between PI and blood Mn (MnB). Results: A total of eight studies with 281 occupationally Mn-exposed workers met the inclusion criteria. Results were pooled and performed with the Meta-analysis. Our data indicated that the PI of the exposed group was significantly higher than that of the control (WMD: 7.76; 95% CI: 4.86, 10.65; I2 = 85.7%, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0093900

DOI: 10.1371/journal.pone.0093900

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