Prognostic Value of Tumor-Infiltrating FoxP3 + T Cells in Gastrointestinal Cancers: A Meta Analysis

Yong Huang, Huaiwei Liao, Yong Zhang, Rongfa Yuan, Fengmei Wang, Yingtang Gao, Peng Wang and Zhi Du

PLOS ONE, 2014, vol. 9, issue 5, 1-12

Abstract: Purpose: Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression. However, its prognostic value for survival in patients with different gastrointestinal cancers [hepatocellular carcinoma (HCC), colorectal cancer (CRC), gastric cancer (GC)] remains controversial. Methods: Relevant literature was searched using PubMed, Embase, Cochrane, Ovid Medline and Chinese wanfang databases. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. The odds ratio (OR) and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: For HCC and GC, the overall survival at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were lower than low FoxP3+ T cells infiltration patients (P 0.05). Conclusions: Our findings suggested that tumor-infiltrating FoxP3+ T cells were a factor for a poor prognosis for HCC and GC, but a good prognosis for CRC.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0094376

DOI: 10.1371/journal.pone.0094376

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