Hemostatic Effects of Microbubble-Enhanced Low-Intensity Ultrasound in a Liver Avulsion Injury Model

Guiying Feng, Jianhua Liu, Xiaochen Zhao, Jinglu Wei, Wencai Ou, Shuyi Xiao, Zhiwen Hu, Hongqin Wei and Zheng Liu

PLOS ONE, 2014, vol. 9, issue 5, 1-8

Abstract: Objectives: Microbubble-enhanced therapeutic ultrasound (MEUS) can block the blood flow in the organs. The aim of this study was to evaluate the hemostatic effect of microbubble-enhanced pulsed, low-intensity ultrasound in a New Zealand White rabbit model of avulsion trauma of the liver. The therapeutic ultrasound (TUS) transducer was operated with the frequency of 1.2 MHz and an acoustic pressure of 3.4 MPa. Microbubble-(MB) enhanced ultrasound (MEUS) (n = 6) was delivered to the distal part of the liver where the avulsion was created. Livers were treated by TUS only (n = 4) or MB only (n = 4) which served as controls. Bleeding rates were measured and contrast enhanced ultrasound (CEUS) was performed to assess the hemostatic effect, and liver hemoperfusion before and after treatment. Generally, bleeding rates decreased more than 10-fold after the treatment with MEUS compared with those of the control group (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0095589

DOI: 10.1371/journal.pone.0095589

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