Patient Self-Management of Oral Anticoagulation with Vitamin K Antagonists in Everyday Practice: Efficacy and Safety in a Nationwide Long-Term Prospective Cohort Study

Michael Nagler, Lucas M Bachmann, Pirmin Schmid, Pascale Raddatz Müller and Walter A Wuillemin

PLOS ONE, 2014, vol. 9, issue 4, 1-9

Abstract: Patient self-management (PSM) of oral anticoagulation is under discussion, because evidence from real-life settings is missing. Using data from a nationwide, prospective cohort study in Switzerland, we assessed overall long-term efficacy and safety of PSM and examined subgroups. Data of 1140 patients (5818.9 patient-years) were analysed and no patient were lost to follow-up. Median follow-up was 4.3 years (range 0.2–12.8 years). Median age at the time of training was 54.2 years (range 18.2–85.2) and 34.6% were women. All-cause mortality was 1.4 per 100 patient-years (95% CI 1.1–1.7) with a higher rate in patients with atrial fibrillation (2.5; 1.6–3.7; p 50 years of age (2.0; 1.6–2.6; p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0095761

DOI: 10.1371/journal.pone.0095761

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