The Differences in Homocysteine Level between Obstructive Sleep Apnea Patients and Controls: A Meta-Analysis

Xun Niu, Xiong Chen, Ying Xiao, Jiaqi Dong, Rui Zhang, Meixia Lu and Weijia Kong

PLOS ONE, 2014, vol. 9, issue 4, 1-7

Abstract: Background: Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies. Methods: Database of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis. Results: A total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 µmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0095794

DOI: 10.1371/journal.pone.0095794

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