Fish Intake and Risk of Liver Cancer: A Meta-Analysis

Rui-Xue Huang, Yan-Ying Duan and Jian-An Hu

PLOS ONE, 2015, vol. 10, issue 1, 1-9

Abstract: Background: Increasing laboratory findings indicate that n-3 fatty acids, mainly derived from fish, inhibit cancer development and progression, but results from epidemiologic studies have been inconsistent and inconclusive. Objective: To evaluate the association of fish intake with risk of liver cancer by conducting a meta-analysis. Methods: Published case-control/cohort studies that evaluated the relationship between total fish intake and risk of liver cancer were found on PubMed and EMBASE. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were obtained with the random-effects model. Results: Five retrospective case-control studies and 5 prospective cohort studies were included in the final analysis, involving a total of 3 624 liver cancer cases. Comparing the highest with the lowest category of total fish intake, the pooled RRs of liver cancer were 0.79 (95% CI, 0.59-1.06) for case-control studies, 0.82 (95% CI, 0.70-0.96) for cohort studies and 0.82 (95% CI, 0.71-0.94) for all studies combined. The protective effects of total fish intake against liver cancer were confirmed by stratified and sensitivity analyses. In addition, an increase in fish intake of 1 serving/week was estimated to be significantly associated with 6% lower risk of liver cancer (RR = 0.94, 95% CI, 0.91-0.98). Conclusions: Findings from this meta-analysis suggest that a higher fish intake is associated with reduced risk of liver cancer.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0096102

DOI: 10.1371/journal.pone.0096102

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