Prognostic Significance of the pN Classification Supplemented by Vascular Invasion for Esophageal Squamous Cell Carcinoma

Chong-Mei Zhu, Yi-Hong Ling, Shao-Yan Xi, Rong-Zhen Luo, Jie-Wei Chen, Jing-Ping Yun, Dan Xie and Mu-Yan Cai

PLOS ONE, 2014, vol. 9, issue 4, 1-9

Abstract: Background: The biological behavior and clinical outcome of esophageal squamous cell carcinoma (ESCC) are difficult to predict. Methodology/Principal Findings: We investigate the prognostic impact of vascular invasion to establish a risk stratification model to predict recurrence and overall survival. We retrospectively evaluated the vascular invasion of 433 patients with ESCC treated with surgery between 2000 and 2007 at a single academic center. Those patients were assigned to a testing cohort and a validation cohort by random number generated in computer. The presence of vascular invasion was observed in 113 of 216 (52.3%) and 96 of 217 (44.2%) of ESCC in the training and validation cohorts, respectively. Further correlation analysis demonstrated that vascular invasion in ESCC was significantly correlated with more advanced pN classification and stage in both cohorts (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0096129

DOI: 10.1371/journal.pone.0096129

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