Simplification to Abacavir/Lamivudine + Atazanavir Maintains Viral Suppression and Improves Bone and Renal Biomarkers in ASSURE, a Randomized, Open Label, Non-Inferiority Trial

David A Wohl, Laveeza Bhatti, Catherine B Small, Howard Edelstein, Henry H Zhao, David A Margolis, Edwin DeJesus, Winkler G Weinberg, Lisa L Ross and Mark S Shaefer

PLOS ONE, 2014, vol. 9, issue 5, 1-10

Abstract: Objective: Simplification of antiretroviral therapy in patients with suppressed viremia may minimize long-term adverse effects. The study’s primary objective was to determine whether abacavir/lamivudine + atazanavir (ABC/3TC+ATV) was virologically non-inferior to tenofovir/emtricitabine + atazanavir/ritonavir (TDF/FTC+ATV/r) over 24 weeks in a population of virologically suppressed, HIV-1 infected patients. Design: This open-label, multicenter, non-inferiority study enrolled antiretroviral experienced, HIV-infected adults currently receiving a regimen of TDF/FTC+ATV/r for ≥6 months with no history of virologic failure and whose HIV-1 RNA had been ≤75 copies/mL on 2 consecutive measurements including screening. Patients were randomized 1∶2 to continue current treatment or simplify to ABC/3TC+ATV. Methods: The primary endpoint was the proportion of patients with HIV-RNA

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0096187

DOI: 10.1371/journal.pone.0096187

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