The Screening Research of Anti-Inflammatory Bioactive Markers from Different Flowering Phases of Flos Lonicerae Japonicae

Min Jiang, Yan-qi Han, Meng-ge Zhou, Hong-zhi Zhao, Xue Xiao, Yuan-yuan Hou, Jie Gao, Gang Bai and Guo-an Luo

PLOS ONE, 2014, vol. 9, issue 5, 1-10

Abstract: Flos Lonicerae Japonicae (FLJ) is an important cash crop in eastern Asia, and it is an anti-inflammatory Traditional Chinese Medicine. There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0096214

DOI: 10.1371/journal.pone.0096214

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