Age-Related Decrease of Meiotic Cohesins in Human Oocytes

Makiko Tsutsumi, Reiko Fujiwara, Haruki Nishizawa, Mayuko Ito, Hiroshi Kogo, Hidehito Inagaki, Tamae Ohye, Takema Kato, Takuma Fujii and Hiroki Kurahashi

PLOS ONE, 2014, vol. 9, issue 5, 1-8

Abstract: Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic chromosomes. In mammalian oocytes, cohesion is established during the fetal stages and meiosis-specific cohesin subunits are not replenished after birth, raising the possibility that the long meiotic arrest of oocytes facilitates a deterioration of cohesion that leads to age-related increases in aneuploidy. We here examined the cohesin levels in dictyate oocytes from different age groups of humans and mice by immunofluorescence analyses of ovarian sections. The meiosis-specific cohesin subunits, REC8 and SMC1B, were found to be decreased in women aged 40 and over compared with those aged around 20 years (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0096710

DOI: 10.1371/journal.pone.0096710

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