Intermediate-Type Vancomycin Resistance (VISA) in Genetically-Distinct Staphylococcus aureus Isolates Is Linked to Specific, Reversible Metabolic Alterations

Elizabeth L Alexander, Susana Gardete, Haim Y Bar, Martin T Wells, Alexander Tomasz and Kyu Y Rhee

PLOS ONE, 2014, vol. 9, issue 5, 1-9

Abstract: Intermediate (VISA-type) vancomycin resistance in Staphylococcus aureus has been associated with a range of physiologic and genetic alterations. Previous work described the emergence of VISA-type resistance in two clonally-distinct series of isolates. In both series (the first belonging to MRSA clone ST8-USA300, and the second to ST5-USA100), resistance was conferred by a single mutation in yvqF (a negative regulator of the vraSR two-component system associated with vancomycin resistance). In the USA300 series, resistance was reversed by a secondary mutation in vraSR. In this study, we combined systems-level metabolomic profiling with statistical modeling techniques to discover specific, reversible metabolic alterations associated with the VISA phenotype.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0097137

DOI: 10.1371/journal.pone.0097137

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