Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis

Yohwan Yeo, Seung-Hyun Ma, Yunji Hwang, Pamela L Horn-Ross, Ann Hsing, Kyu-Eun Lee, Young Joo Park, Do-Joon Park, Keun-Young Yoo and Sue K Park

PLOS ONE, 2014, vol. 9, issue 6, 1-11

Abstract: Introduction: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. Methods: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. Results: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11–1.63). However, there was heterogeneity in the results (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0098135

DOI: 10.1371/journal.pone.0098135

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