Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

Meixiao Shen, Pingping Hu, Frede Donskov, Guanghui Wang, Qi Liu and Jiajun Du

PLOS ONE, 2014, vol. 9, issue 6, 1-10

Abstract: Purpose: Tumor-associated neutrophils (TAN) have been reported in a variety of malignancies. We conducted an up-to-date meta-analysis to evaluate the prognostic role of TAN in cancer. Method: Pubmed, Embase and web of science databases were searched for studies published up to April 2013. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. The impact of neutrophils localization and primary antibody were also assessed. Results: A total of 3946 patients with various solid tumors from 20 studies were included. High density of intratumoral neutrophils were independently associated with unfavorable survival; the pooled HRs were 1.68 (95%CI: 1.36–2.07, I2 = 55.8%, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0098259

DOI: 10.1371/journal.pone.0098259

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