Enhancement Characteristics and Impact on Image Quality of Two Gadolinium Chelates at Equimolar Doses for Time-Resolved 3-Tesla MR-Angiography of the Calf Station

Jan Hansmann, Henrik J Michaely, John N Morelli, André Luckscheiter, Stefan O Schoenberg and Ulrike I Attenberger

PLOS ONE, 2014, vol. 9, issue 6, 1-5

Abstract: Purpose: To compare enhancement characteristics and image quality of two macrocyclic gadolinium chelates, gadoterate meglumine and gadobutrol, in low-dose, time-resolved MRA of the calf station. Materials and Methods: 100 consecutive patients with peripheral arterial disease (stages II-IV) were retrospectively analysed. Fifty patients were included in each group - 32 men and 18 women for gadobutrol (mean age 67 years) and 34 men, 16 women for gadoterate meglumine (mean age 64 years). 0.03 mmol/kg bw of either gadobutrol or gadoterate meglumine was injected. Gadobutrol was diluted 1∶1 with normal saline (0.9% NaCl) to provide similar injection volume and bolus geometry compared to the undiluted 0.5 M dose of gadoterate meglumine. Signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR) and image quality were analysed and compared between the two groups. Results: Mean SNR ranged from 83.0±46.7 (peroneal artery) to 96.4±64.5 (anterior tibial artery) for gadobutrol, and from 37.6±13.8 (peroneal artery) to 45.3±16.4 (anterior tibial artery) for the gadoterate meglumine group (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0099079

DOI: 10.1371/journal.pone.0099079

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