Association between Tumor Necrosis Factor-α rs1800629 Polymorphism and Risk of Asthma: A Meta-Analysis

Guangdie Yang, Junjun Chen, Fei Xu, Zhang Bao, Yake Yao and Jianying Zhou

PLOS ONE, 2014, vol. 9, issue 6, 1-11

Abstract: Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility. Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21–1.76, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0099962

DOI: 10.1371/journal.pone.0099962

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