Admission Cell Free DNA Levels Predict 28-Day Mortality in Patients with Severe Sepsis in Intensive Care

Avital Avriel, Maya Paryente Wiessman, Yaniv Almog, Yael Perl, Victor Novack, Ori Galante, Moti Klein, Michael J Pencina and Amos Douvdevani

PLOS ONE, 2014, vol. 9, issue 6, 1-7

Abstract: Aim: The aim of the current study is to assess the mortality prediction accuracy of circulating cell-free DNA (CFD) level at admission measured by a new simplified method. Materials and Methods: CFD levels were measured by a direct fluorescence assay in severe sepsis patients on intensive care unit (ICU) admission. In-hospital and/or twenty eight day all-cause mortality was the primary outcome. Results: Out of 108 patients with median APACHE II of 20, 32.4% have died in hospital/or at 28-day. CFD levels were higher in decedents: median 3469.0 vs. 1659 ng/ml, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0100514

DOI: 10.1371/journal.pone.0100514

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