miR-485-5p Binding Site SNP rs8752 in HPGD Gene Is Associated with Breast Cancer Risk

Na He, Hong Zheng, Pei Li, Yanrui Zhao, Wei Zhang, Fengju Song and Kexin Chen

PLOS ONE, 2014, vol. 9, issue 7, 1-7

Abstract: Background: Single nucleotide polymorphisms (SNPs) that reside in microRNA target sites may play an important role in breast cancer development and progression. To reveal the association between microRNA target site SNPs and breast cancer risk, we performed a large case-control study in China. Methods: We performed a two-stage case-control study including 2744 breast cancer cases and 3125 controls. In Stage I, we genotyped 192 SNPs within microRNA binding sites identified from the “Patrocles” database using custom Illumina GoldenGate VeraCode assays on the Illumina BeadXpress platform. In Stage II, genotyping was performed on SNPs potentially associated with breast cancer risk using the TaqMan platform in an independent replication set. Results: In stage I, 15 SNPs were identified to be significantly associated with breast cancer risk (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0102093

DOI: 10.1371/journal.pone.0102093

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