Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt: A Potential Mechanism of Migraine and Cryptogenic Stroke

Zhen-Ni Guo, Yingqi Xing, Jia Liu, Shuang Wang, Shuo Yan, Hang Jin and Yi Yang

PLOS ONE, 2014, vol. 9, issue 8, 1-6

Abstract: Background and Purpose: The relationship between right-to-left shunts (RLS) and migraine and cryptogenic stroke is not well understood. In this study, we investigated whether RLS are associated with impairment of dynamic cerebral autoregulation (dCA), which may play a role in migraine and cryptogenic stroke. Methods: Sixty-six migraineurs were enrolled in the study, including 36 non-RLS patients and 30 RLS patients. Non-invasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously from each patient by using transcranial Doppler and servo-controlled plethysmograph, respectively. Transfer function analysis was applied to derive autoregulatory parameters of gain, phase difference (PD), and autoregulation index. Results: The PD in migraineurs with RLS was 50.6±22.9 degrees, which was significantly lower than that observed in the non-RLS group (67.2±18.2 degrees, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0104849

DOI: 10.1371/journal.pone.0104849

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