Adjuvant and Salvage Radiotherapy after Prostatectomy: A Systematic Review and Meta-Analysis

Changhao Chen, Tianxin Lin, Yu Zhou, Doudou Li, Kewei Xu, Zhihua Li, Xinxiang Fan, Guangzheng Zhong, Wang He, Xu Chen, Xianyin He and Jian Huang

PLOS ONE, 2014, vol. 9, issue 8, 1-14

Abstract: Purpose: In men with adverse prognostic factors (APFs) after radical prostatectomy (RP), the most appropriate timing to administer radiotherapy remains a subject for debate. We conducted a systemic review and meta-analysis to evaluate the therapeutic strategies: adjuvant radiotherapy (ART) and salvage radiotherapy (SRT). Materials and Methods: We comprehensively searched PubMed, EMBASE, Web of Science and the Cochrane Library and performed the meta-analysis of all randomized controlled trials (RCTs) and retrospective comparative studies assessing the prognostic factors of ART and SRT. Results: Between May 1998 and July 2012, 2 matched control studies and 16 retrospective studies including a total of 2629 cases were identified (1404 cases for ART and 1185 cases for SRT). 5-year biochemical failure free survival (BFFS) for ART was longer than that for SRT (Hazard Ratio [HR]: 0.37; 95% CI, 0.30–0.46; p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0104918

DOI: 10.1371/journal.pone.0104918

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