Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis

Jun-Xia Cao, Xiao-Yan Zhang, Jin-Long Liu, Duo Li, Jun-Li Li, Yi-Shan Liu, Min Wang, Bei-Lei Xu, Hai-Bo Wang and Zheng-Xu Wang

PLOS ONE, 2014, vol. 9, issue 9, 1-12

Abstract: Background: The effectiveness of immunotherapy for high-grade glioma (HGG) patients remains controversial. To evaluate the therapeutic efficacy of dendritic cells (DCs) alone in the treatment of HGG, we performed a systematic review and meta-analysis in terms of patient survival with relevant published clinical studies. Materials and methods: A total of 409 patients, including historical cohorts, nonrandomized and randomized controls with HGG, were selected for the meta-analysis. Results: The treatment of HGG with DCs was associated with a significantly improved one-year survival (OS) (p 0.05), whereas CD56+ lymphocyte subset were significantly increased after DC treatment (p = 0.0001). Furthermore, the levels of IFN-γ in the peripheral blood of HGG patients, which reflect the immune function of the patients, were significantly increased after DC immunotherapy (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0107173

DOI: 10.1371/journal.pone.0107173

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