Increased Risk of Acute Angle Closure in Retinitis Pigmentosa: A Population-Based Case-Control Study

Yu-Chieh Ko, Chia-Jen Liu, Hwang De-Kuang, Tzeng-Ji Chen and Catherine J Liu

PLOS ONE, 2014, vol. 9, issue 9, 1-5

Abstract: Purpose: To investigate the association between retinitis pigmentosa (RP) and acute angle closure during a 15-year follow-up period. Methods: Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 382 RP patients based on the diagnostic code of RP (International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) 362.74) made during 1996–2010, excluding subjects under age of 20 years at diagnosis or subjects undergoing lens extraction before the index date. The control group included 3820 randomly selected non-RP subjects matched with the RP patients in age, gender and the index date of diagnosis. The incidence of acute angle closure during the study period was observed based on an ICD-9-CM code of 365.22. Cochran-Mantel-Haenszel test was used to determine the odds ratio (OR) of having acute angle closure in RP patients. Results: The mean age at the diagnosis of RP was 51.1years (standard deviation [SD] 16.7). Acute angle closure occurred in 5 RP patients (1.3%) and in 15 controls (0.4%). The mean age with the acute angle closure was 53.3 years (SD 8.0) in RP patients and 64.6 years (SD 8.4) in controls (P = 0.015). After adjusting for age, gender and comorbid disorders, RP patients had 3.64-fold (95% confidence interval [CI], 1.29–10.25, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0107660

DOI: 10.1371/journal.pone.0107660

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