Gene-Based Rare Allele Analysis Identified a Risk Gene of Alzheimer’s Disease

Jong Hun Kim, Pamela Song, Hyunsun Lim, Jae-Hyung Lee, Jun Hong Lee, Sun Ah Park and for the Alzheimer’s Disease Neuroimaging Initiative

PLOS ONE, 2014, vol. 9, issue 10, 1-8

Abstract: Alzheimer’s disease (AD) has a strong propensity to run in families. However, the known risk genes excluding APOE are not clinically useful. In various complex diseases, gene studies have targeted rare alleles for unsolved heritability. Our study aims to elucidate previously unknown risk genes for AD by targeting rare alleles. We used data from five publicly available genetic studies from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the database of Genotypes and Phenotypes (dbGaP). A total of 4,171 cases and 9,358 controls were included. The genotype information of rare alleles was imputed using 1,000 genomes. We performed gene-based analysis of rare alleles (minor allele frequency≤3%). The genome-wide significance level was defined as meta P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0107983

DOI: 10.1371/journal.pone.0107983

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