Retrospective Analysis of 234 Nasopharyngeal Carcinoma Patients with Distant Metastasis at Initial Diagnosis: Therapeutic Approaches and Prognostic Factors

Lei Zeng, Yun-Ming Tian, Ying Huang, Xue-Ming Sun, Feng-Hua Wang, Xiao-Wu Deng, Fei Han and Tai-Xiang Lu

PLOS ONE, 2014, vol. 9, issue 9, 1-8

Abstract: Purpose: The purpose of this retrospective study was to identify the independent prognostic factors and optimize the treatment for nasopharyngeal carcinoma (NPC) patients with distant metastasis at initial diagnosis. Methods: A total of 234 patients referred between January 2001 and December 2010 were retrospectively analyzed. Among the 234 patients, 94 patients received chemotherapy alone (CT), and 140 patients received chemoradiotherapy (CRT). Clinical features, laboratory parameters and treatment modality were examined with univariate and multivariate analyses. Results: The median overall survival (OS) time was 22 months (range, 2-125 months), and the 1-year, 2-year, 3-year overall survival rates were 82.2%, 51.3% and 34.1%. The overall response and disease control rates of metastatic lesions after chemotherapy were 56.0% and 89.8%. The factors associated with poor response were karnofsky performance score (KPS) 245 IU/L, and number of chemotherapy cycles

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0108070

DOI: 10.1371/journal.pone.0108070

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