Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer

Anne Benard, Inès J Goossens-Beumer, Anneke Q van Hoesel, Hamed Horati, Hein Putter, Eliane C M Zeestraten, Cornelis J H van de Velde and Peter J K Kuppen

PLOS ONE, 2014, vol. 9, issue 9, 1-11

Abstract: Numerous changes in epigenetic mechanisms have been described in various types of tumors. In search for new biomarkers, we investigated the expression of Polycomb-group (PcG) proteins EZH2, BMI1 and SUZ12 and associated histone modification H3K27me3 in colorectal cancer. Nuclear expression of PcG proteins and histone modification H3K27me3 were immunohistochemically (IHC) stained on a tissue microarray (TMA), including 247 tumor tissues and 47 normal tissues, and scored using the semi-automated Ariol system. Tumor tissues showed higher expression of EZH2 (p = 0.05) and H3K27me3 (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0108265

DOI: 10.1371/journal.pone.0108265

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