Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Lidyane V Camelo, Luana Giatti, Jorge Alexandre Barbosa Neves, Paulo A Lotufo, Isabela M Benseñor, Dóra Chor, Rosane Härter Griep, Maria de Jesus Mendes da Fonseca, Pedro Guatimosim Vidigal, Ichiro Kawachi, Maria Inês Schmidt and Sandhi Maria Barreto

PLOS ONE, 2014, vol. 9, issue 10, 1-12

Abstract: Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association between life course SEP and C-reactive protein (CRP) levels in adulthood, and to evaluate the extent to which health-risk behaviors and metabolic alterations mediate this association. Additionally, we explored the possible modifying influence of gender. Methods and Findings: Our analytical sample comprised 13,371 participants from ELSA-Brasil baseline, a multicenter prospective cohort study of civil servants. SEP during childhood, young adulthood, and adulthood were considered. The potential mediators between life course SEP and CRP included clusters of health-risk behaviors (smoking, low leisure time physical activity, excessive alcohol consumption), and metabolic alterations (obesity, hypertension, low HDL, hypertriglyceridemia, and diabetes). Linear regression models were performed and structural equation modeling was used to evaluate mediation. Although lower childhood SEP was associated with higher levels of CRP in adult life, this association was not independent of adulthood SEP. However, CRP increased linearly with increasing number of unfavorable social circumstances during the life course (p trend

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0108426

DOI: 10.1371/journal.pone.0108426

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