Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

Jennifer K Frediani, Dean P Jones, Nestan Tukvadze, Karan Uppal, Eka Sanikidze, Maia Kipiani, ViLinh T Tran, Gautam Hebbar, Douglas I Walker, Russell R Kempker, Shaheen S Kurani, Romain A Colas, Jesmond Dalli, Vin Tangpricha, Charles N Serhan, Henry M Blumberg and Thomas R Ziegler

PLOS ONE, 2014, vol. 9, issue 10, 1-9

Abstract: We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well as biomarkers of TB onset, progression and resolution. Such data may inform development of new anti-tuberculosis drugs. Plasma samples from adults with newly diagnosed pulmonary TB disease and their matched, asymptomatic, sputum culture-negative household contacts were analyzed using liquid chromatography high-resolution mass spectrometry (LC-MS) to identify metabolites. Statistical and bioinformatics methods were used to select accurate mass/charge (m/z) ions that were significantly different between the two groups at a false discovery rate (FDR) of q

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0108854

DOI: 10.1371/journal.pone.0108854

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