Comparison of Serological Response to Doxycycline versus Benzathine Penicillin G in the Treatment of Early Syphilis in HIV-Infected Patients: A Multi-Center Observational Study

Jen-Chih Tsai, Yu-Huei Lin, Po-Liang Lu, Ni-Jiin Shen, Chia-Jui Yang, Nan-Yao Lee, Hung-Jen Tang, Yuag-Meng Liu, Wen-Chi Huang, Chen-Hsiang Lee, Wen-Chien Ko, Yen-Hsu Chen, Hsi-Hsun Lin, Tun-Chieh Chen and Chien-Ching Hung

PLOS ONE, 2014, vol. 9, issue 10, 1-7

Abstract: Background: While doxycycline is recommended as an alternative treatment of syphilis in patients with penicillin allergy or intolerance, clinical studies to compare serological response to doxycycline versus benzathine penicillin in treatment of early syphilis among HIV-infected patients remain sparse. Methods: We retrospectively reviewed the medical records of HIV-infected patients with early syphilis who received doxycycline 100 mg twice daily for 14 days (doxycycline group) and those who received 1 dose of benzathine penicillin (2.4 million units) (penicillin group) between 2007 and 2013. Serological responses defined as a decline of rapid plasma reagin titer by 4-fold or greater at 6 and 12 months of treatment were compared between the two groups. Results: During the study period, 123 and 271 patients in the doxycycline and penicillin group, respectively, completed 6 months or longer follow-up. Ninety-one and 271 patients in the doxycycline and penicillin group, respectively, completed 12 months or longer follow-up. Clinical characteristics were similar between the two groups, except that, compared with penicillin group, doxycycline group had a lower proportion of patients with secondary syphilis (65.4% versus 41.5%, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0109813

DOI: 10.1371/journal.pone.0109813

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