Effect of Vitamin D Supplementation on Cardiometabolic Risks and Health-Related Quality of Life among Urban Premenopausal Women in a Tropical Country – A Randomized Controlled Trial

Mazliza Ramly, Moy Foong Ming, Karuthan Chinna, Suhaili Suboh and Rokiah Pendek

PLOS ONE, 2014, vol. 9, issue 10, 1-11

Abstract: Background: Many observational studies linked vitamin D to cardiometabolic risks besides its pivotal role in musculoskeletal diseases, but evidence from trials is lacking and inconsistent. Aim: To determine whether Vitamin D supplementation in urban premenopausal women with vitamin D deficiency can improve cardiometabolic risks and health-related quality of life (HRQOL). Design: A double-blind randomized controlled trial was conducted in Kuala Lumpur, Malaysia. A total of 192 vitamin D deficient ( 0.05) between two groups. There was a small but significant improvement in HRQOL in the components of vitality (mean difference: 5.041; 95% CI: 0.709 to 9.374) and mental component score (mean difference: 2.951; 95% CI: 0.573 to 5.329) in the intervention group compared to placebo group. Conclusion: Large and less frequent dosage vitamin D supplementation was safe and effective in the achievement of vitamin D sufficiency. However, there was no improvement in measured cardiometabolic risk factors in premenopausal women. Conversely vitamin D supplementation improves some components of HRQOL. Trial Registration: Australian New Zealand Clinical Trial Registry ACTRN12612000452897

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0110476

DOI: 10.1371/journal.pone.0110476

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