Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial

Bart J A Mertens, Wilco C H Jacobs, Ronald Brand and Wilco C Peul

PLOS ONE, 2014, vol. 9, issue 10, 1-7

Abstract: We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individual patient level in a re-analysis of the wait-and-see group data. Both marginal structural model re-weighted estimates as well as propensity score adjusted analyses are presented. Results indicate that patients with high propensity to receive surgery may have beneficial effects at 2 years from delayed disc surgery.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0111325

DOI: 10.1371/journal.pone.0111325

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