Effects of Treatment with Zofenopril in Men and Women with Acute Myocardial Infarction: Gender Analysis of the SMILE Program

Flavia Franconi, Stefano Omboni, Ettore Ambrosioni, Giorgio Reggiardo, Ilaria Campesi and Claudio Borghi

PLOS ONE, 2014, vol. 9, issue 11, 1-8

Abstract: Background: the SMILE studies proved the prognostic benefit of zofenopril vs. placebo or other ACE-inhibitors (ACEIs) in post-acute myocardial infarction (AMI). In this retrospective pooled analysis of these studies we assessed whether the zofenopril effect is influenced by gender. Methods: the four double-blind, randomized, parallel-group SMILE studies, compared the efficacy and safety of 6–48 week treatment with zofenopril 60 mg/day with that of placebo, lisinopril 10 mg/day or ramipril 10 mg/day in 3630 AMI patients. This pooled analysis compared treatment efficacy (1-year combined occurrence of death or hospitalization for CV causes) in 2733 men and 897 women. Results: women were older than men, had a higher prevalence of diabetes and of other major CV risk factors. The risk of a major CV event was significantly larger for women (23% vs. 17% men, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0111558

DOI: 10.1371/journal.pone.0111558

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