Association of HLA-DP/DQ and STAT4 Polymorphisms with HBV Infection Outcomes and a Mini Meta-Analysis

Yun Liao, Bei Cai, Yi Li, Jie Chen, Chuanmin Tao, Hengjian Huang and Lanlan Wang

PLOS ONE, 2014, vol. 9, issue 11, 1-9

Abstract: Background: Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC) development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships. Methods: We recruited 1312 Chinese Han subjects including healthy controls, HBV carriers and HCC patients in the experiment stage. The meta-analysis included 3467 HCC patients and 5821 HBV carriers to appraise the association with HCC development. Results: Consistent with previous studies, HLA-DP/DQ associated with HBV susceptibility and HBV natural clearance (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0111677

DOI: 10.1371/journal.pone.0111677

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