Safety and Effectiveness of Combination Antiretroviral Therapy during the First Year of Treatment in HIV-1 Infected Rwandan Children: A Prospective Study

Philippe R Mutwa, Kimberly R Boer, Brenda Asiimwe-Kateera, Diane Tuyishimire, Narcisse Muganga, Joep M A Lange, Janneke van de Wijgert, Anita Asiimwe, Peter Reiss and Sibyl P M Geelen

PLOS ONE, 2014, vol. 9, issue 11, 1-12

Abstract: Background: With increased availability of paediatric combination antiretroviral therapy (cART) in resource limited settings, cART outcomes and factors associated with outcomes should be assessed. Methods: HIV-infected children −2, immunological success as CD4 cells ≥500/mm3 and ≥25% for respectively children over 5 years and under 5 years, and virological success as a plasma HIV-1 RNA concentration 1000 c/mL). Older age at cART initiation, poor adherence, and exposure to antiretrovirals around birth were associated with virological failure. A third (33%) of children had side effects (by self-report or clinical assessment), but only 9% experienced a severe side effect requiring a cART regimen change. Conclusions: cART in Rwandan HIV-infected children was successful but success might be improved further by initiating cART as early as possible, optimizing adherence and optimizing management of side effects.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0111948

DOI: 10.1371/journal.pone.0111948

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