Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population

Ai Haraguchi, Naomi Hayashida, Toshihiko Kamasaki, Izumi Miyamoto, Toshiya Usui, Takao Ando, Norio Abiru, Hironori Yamasaki, Kenya Chiba, Takashi Kudo, Atsushi Kawakami and Noboru Takamura

PLOS ONE, 2014, vol. 9, issue 11, 1-7

Abstract: Objective: This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. Methods: 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. Results: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (β = 0.001, p = 0.03) and log-leptin (β = 0.336, p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0111990

DOI: 10.1371/journal.pone.0111990

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