Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics

Li Chen, Peter L Choyke, Niya Wang, Robert Clarke, Zaver M Bhujwalla, Elizabeth M C Hillman, Ge Wang and Yue Wang

PLOS ONE, 2014, vol. 9, issue 11, 1-9

Abstract: With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartment modeling (MTCM), a completely unsupervised method of deconvoluting dynamic imaging series from heterogeneous tumors that can improve vascular characterization in many biological contexts. Applying MTCM to dynamic contrast-enhanced magnetic resonance imaging of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable. MTCM is readily applicable to other dynamic imaging modalities for studying intratumor functional and phenotypic heterogeneity, together with a variety of foreseeable applications in the clinic.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0112143

DOI: 10.1371/journal.pone.0112143

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