Protein Interaction Networks Reveal Novel Autism Risk Genes within GWAS Statistical Noise

Catarina Correia, Guiomar Oliveira and Astrid M Vicente

PLOS ONE, 2014, vol. 9, issue 11, 1-11

Abstract: Genome-wide association studies (GWAS) for Autism Spectrum Disorder (ASD) thus far met limited success in the identification of common risk variants, consistent with the notion that variants with small individual effects cannot be detected individually in single SNP analysis. To further capture disease risk gene information from ASD association studies, we applied a network-based strategy to the Autism Genome Project (AGP) and the Autism Genetics Resource Exchange GWAS datasets, combining family-based association data with Human Protein-Protein interaction (PPI) data. Our analysis showed that autism-associated proteins at higher than conventional levels of significance (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0112399

DOI: 10.1371/journal.pone.0112399

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