Naloxone for Severe Traumatic Brain Injury: A Meta-Analysis

Hengzhu Zhang, Xiaodong Wang, Yuping Li, Renfei Du, Enxi Xu, Lun Dong, Xingdong Wang, Zhengcun Yan, Lujun Pang, Min Wei and Lei She

PLOS ONE, 2014, vol. 9, issue 12, 1-15

Abstract: Objective: The efficiency of naloxone for the management of secondary brain injury after severe traumatic brain injury (sTBI) remains undefined. The aim of this study is to evaluate the current evidence regarding the clinical efficiency and safety of naloxone as a treatment for sTBI in mainland China. Methodology/Principal Findings: A systematic search of the China Biology Medicine disc (CBM), China Science and Technology Journal Database (VIP), China National Knowledge Internet (CNKI), and Wan Fang Database was performed to identify randomized controlled trials (RCTs) of naloxone treatment for patients with sTBI in mainland China. The quality of the included trials was assessed, and the RevMan 5.1 software was employed to conduct this meta-analysis. Nineteen RCTs including 2332 patients were included in this study. The odds ratio (OR) showed statistically significant differences between the naloxone group and the control group (placebo) in terms of mortality at 18 months after treatment (OR, 0.51, 95%CI: 0.38–0.67; p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0113093

DOI: 10.1371/journal.pone.0113093

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