Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis

Jing-Xun Wu, Yuan-Yuan Zhao, Xuan Wu and Han-Xiang An

PLOS ONE, 2014, vol. 9, issue 12, 1-13

Abstract: Objective: The prognostic significance of CD24 expression for survival in patients with gastric cancer remains controversial. We conducted a meta-analysis to investigate the impact of CD24 expression on clinicopathological features and survival outcomes in gastric cancer. Methods: A comprehensive literature search of the electronic databases PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI; up to April 8, 2014) was performed for relevant studies using multiple search strategies. Correlations between CD24 expression and clinicopathological features and overall survival (OS) were analyzed. Results: A total of 1,041 patients with gastric cancer from 9 studies were included. The pooled odds ratios (ORs) indicated CD24 expression was associated with tumor depth (OR = 0.45, 95% confidence interval [CI] = 0.32–0.63; P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0114746

DOI: 10.1371/journal.pone.0114746

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