Sarcopenia as a Prognostic Biomarker of Advanced Urothelial Carcinoma

Hiroshi Fukushima, Minato Yokoyama, Yasukazu Nakanishi, Ken-ichi Tobisu and Fumitaka Koga

PLOS ONE, 2015, vol. 10, issue 1, 1-11

Abstract: Objectives: Sarcopenia, a novel concept reflecting the degenerative loss of skeletal muscle mass, is an objective indicator of cancer cachexia. We investigated its role as a prognostic biomarker in advanced urothelial carcinoma (UC) patients. Methods: This retrospective study consisted of 88 UC patients with cT4 and/or metastases to lymph nodes/distant organs. Skeletal muscle index (SMI), an indicator of whole-body muscle mass, was measured from computed tomography (CT) images at the diagnosis. Sarcopenia was defined as SMIs of

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0115895

DOI: 10.1371/journal.pone.0115895

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