The Effect of Disease Modifying Therapies on Brain Atrophy in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis

Georgios Tsivgoulis, Aristeidis H Katsanos, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Ioannis Heliopoulos, Constantinos Kilidireas and Konstantinos Voumvourakis

PLOS ONE, 2015, vol. 10, issue 3, 1-10

Abstract: Background: The aim of the present meta-analysis was to evaluate the effect of disease-modifying drugs (DMD) on brain atrophy in patients with relapsing-remitting multiple sclerosis (RRMS) using available randomized-controlled trial (RCT) data. Methods: We conducted a systematic review and meta-analysis according to PRISMA guidelines of all available RCTs of patients with RRMS that reported data on brain volume measurements during the study period. Results: We identified 4 eligible studies, including a total of 1819 RRMS patients (71% women, mean age 36.5 years, mean baseline EDSS-score: 2.4). The mean percentage change in brain volume was found to be significantly lower in DMD versus placebo subgroup (standardized mean difference: -0.19; 95%CI: -0.27–-0.11; p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0116511

DOI: 10.1371/journal.pone.0116511

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