Synergistic Impaired Effect between Smoking and Manganese Dust Exposure on Pulmonary Ventilation Function in Guangxi Manganese-Exposed Workers Healthy Cohort (GXMEWHC)

Fenfen Wang, Yunfeng Zou, Yuefei Shen, Yaoqiu Zhong, Yingnan Lv, Damin Huang, Kangcheng Chen, Qin Li, Li Qing, Bing Xia, Cheng Su, Shuyan Ma and Xiaobo Yang

PLOS ONE, 2015, vol. 10, issue 2, 1-11

Abstract: Purpose: The aims of this study were to investigate the effects of manganese (Mn) dust exposure on lung functions and evaluate the potential synergistic effect between smoking and Mn dust exposure among refinery workers. Methods: A retrospective study including 1658 workers in a ferromanganese refinery was conducted, with subjects who were from the Guangxi manganese-exposed workers healthy cohort (GXMEWHC). Based on the Mn manganese cumulative exposure index (Mn-CEI), all subjects were divided into the low exposure group (n = 682) and the high exposure group (n = 976). A pulmonary function test was performed using an electronic spirometer, including the values and percentages of FVC, FEV1, FEV1/FVC, MMEF, PEFR, MVV, respectively. Results: No significant effect of Mn dust exposure on the pulmonary function was found in the female workers (all p>0.05). However, there was an obvious decrease in the male workers in the high exposure group compared with those in the low exposure group (FVC -60 ml, FEV1 -120 ml, MMEF -260 ml/s, MVV -5.06 L, all p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0116558

DOI: 10.1371/journal.pone.0116558

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