The Prognostic Role of mTOR and P-mTOR for Survival in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Lei Li, Dan Liu, Zhi-Xin Qiu, Shuang Zhao, Li Zhang and Wei-Min Li

PLOS ONE, 2015, vol. 10, issue 2, 1-13

Abstract: Objectives: The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). However, the association between mTOR/p-mTOR expression and NSCLC patients’ prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSCLC was conducted. Materials and Methods: A systemically literature search was performed via Pubmed, Embase, Medline as well as CNKI (China National Knowledge Infrastructure). Studies were included that reported the hazard ratio (HR) and 95%CI for the association between mTOR/p-mTOR expression and NSCLC patients’ survival. Random-effects model was used to pool HRs. Results: Ten eligible studies were included in this meta-analysis, with 4 about m-TOR and 7 about p-mTOR. For mTOR, the pooled HR of overall survival (OS) was 1.00 (95%CI 0.5 to 1.99) by univariate analysis and 1.22 (95%CI 0.53 to 2.82) by multivariate analysis. For p-mTOR, the pooled HR was 1.39 (95%CI 0.97 to 1.98) by univariate analysis and 1.42 (95%CI 0.56 to 3.60) by multivariate analysis. Conclusion: The results indicated that no statistically significant association was found between mTOR/p-mTOR expression and NSCLC patients’ prognosis.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0116771

DOI: 10.1371/journal.pone.0116771

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