A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes

Lei Chen, Chen Chu, Xiangyin Kong, Guohua Huang, Tao Huang and Yu-Dong Cai

PLOS ONE, 2015, vol. 10, issue 3, 1-15

Abstract: Uncovering the molecular mechanisms underlying reproduction is of great importance to infertility treatment and to the generation of healthy offspring. In this study, we discovered novel reproduction-related genes with a hybrid computational method, integrating three different types of method, which offered new clues for further reproduction research. This method was first executed on a weighted graph, constructed based on known protein-protein interactions, to search the shortest paths connecting any two known reproduction-related genes. Genes occurring in these paths were deemed to have a special relationship with reproduction. These newly discovered genes were filtered with a randomization test. Then, the remaining genes were further selected according to their associations with known reproduction-related genes measured by protein-protein interaction score and alignment score obtained by BLAST. The in-depth analysis of the high confidence novel reproduction genes revealed hidden mechanisms of reproduction and provided guidelines for further experimental validations.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117090

DOI: 10.1371/journal.pone.0117090

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