Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk

Hannah Arem, Kai Yu, Xiaoqin Xiong, Kristin Moy, Neal D Freedman, Susan T Mayne, Demetrius Albanes, Alan A Arslan, Melissa Austin, William R Bamlet, Laura Beane-Freeman, Paige Bracci, Federico Canzian, Michelle Cotterchio, Eric J Duell, Steve Gallinger, Graham G Giles, Michael Goggins, Phyllis J Goodman, Patricia Hartge, Manal Hassan, Kathy Helzlsouer, Brian Henderson, Elizabeth A Holly, Robert Hoover, Eric J Jacobs, Aruna Kamineni, Alison Klein, Eric Klein, Laurence N Kolonel, Donghui Li, Núria Malats, Satu Männistö, Marjorie L McCullough, Sara H Olson, Irene Orlow, Ulrike Peters, Gloria M Petersen, Miquel Porta, Gianluca Severi, Xiao-Ou Shu, Kala Visvanathan, Emily White, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Geoffrey S Tobias, Dennis Maeder, Michelle Brotzman, Harvey Risch, Joshua N Sampson and Rachael Z Stolzenberg-Solomon

PLOS ONE, 2015, vol. 10, issue 3, 1-10

Abstract: Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Our study included 3,583 pancreatic cancer cases and 7,053 controls from the genome-wide association studies of pancreatic cancer PanScans-I-III. We used the Adaptive Joint Test and the Adaptive Rank Truncated Product statistic for pathway and gene analyses, and unconditional logistic regression for SNP analyses, adjusting for age, sex, study and population stratification. We examined effect modification by circulating vitamin D concentration (≤50, >50 nmol/L) for the most significant SNPs using a subset of cohort cases (n = 713) and controls (n = 878). The vitamin D metabolic pathway was not associated with pancreatic cancer risk (p = 0.830). Of the individual genes, none were associated with pancreatic cancer risk at a significance level of p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117574

DOI: 10.1371/journal.pone.0117574

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