A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles

Gudrun Schappacher-Tilp, Timothy Leonard, Gertrud Desch and Walter Herzog

PLOS ONE, 2015, vol. 10, issue 3, 1-16

Abstract: We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117634

DOI: 10.1371/journal.pone.0117634

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