The Association of Normal Range Glycated Hemoglobin with Restrictive Lung Pattern in the General Population

Il Hwan Oh, Jung Hwan Park, Chang Hwa Lee and Joon-Sung Park

PLOS ONE, 2015, vol. 10, issue 2, 1-10

Abstract: Glycated hemoglobin (HbA1c) is an important diagnostic indicator of diabetes mellitus, and some authors have argued that it is related to impaired lung function in the diabetic population. However, there was rare study for association between lung function and HbA1c in the non-diabetic population. We investigated whether HbA1c below the diagnostic threshold is related to deficits in lung function. We analyzed biochemical and spirometry data from a nation-wide, population-based, case-control study (the KNHANES IV and V). Eligible as cases were all native Koreans aged 40 years or more with no medical illness. A total of 3670 participants were divided into 4 groups according to HbA1c (%) as follows: Group I (n = 842), ≥ 4.0 and ≤ 5.3; Group II (n = 833), > 5.3 and ≤ 5.5; Group III (n = 898), > 5.5 and ≤ 5.7; and Group IV (n = 1097), > 5.7 and ≤ 6.4. Group I had the greatest forced vital capacity (FVC, 96.3 ± 0.5% pred, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117725

DOI: 10.1371/journal.pone.0117725

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