Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia

Mitsuhiko Kawano, Ken Sawada, Shinji Shimodera, Yasuhiro Ogawa, Shinji Kariya, Donna J Lang, Shimpei Inoue and William G Honer

PLOS ONE, 2015, vol. 10, issue 2, 1-14

Abstract: Background: Reduced hippocampal volume in schizophrenia is a well-replicated finding. New imaging techniques allow delineation of hippocampal subfield volumes. Studies including predominantly chronic patients demonstrate differences between subfields in sensitivity to illness, and in associations with clinical features. We carried out a cross-sectional and longitudinal study of first episode, sub-chronic, and chronic patients, using an imaging strategy that allows for the assessment of multiple hippocampal subfields. Methods: Hippocampal subfield volumes were measured in 34 patients with schizophrenia (19 first episode, 6 sub-chronic, 9 chronic) and 15 healthy comparison participants. A subset of 10 first episode and 12 healthy participants were rescanned after six months. Results: Total left hippocampal volume was smaller in sub-chronic (p = 0.04, effect size 1.12) and chronic (p = 0.009, effect size 1.42) patients compared with healthy volunteers. The CA2-3 subfield volume of chronic patients was significantly decreased (p = 0.009, effect size 1.42) compared to healthy volunteers. The CA4-DG volume was significantly reduced in all three patient groups compared to healthy group (all p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117785

DOI: 10.1371/journal.pone.0117785

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