Predictive and Prognostic Value of Metabolic Tumor Volume (MTV) in Patients with Laryngeal Carcinoma Treated by Radiotherapy (RT) / Concurrent Chemoradiotherapy (CCRT)

Kenichiro Yabuki, Osamu Shiono, Masanori Komatsu, Daisuke Sano, Goshi Nishimura, Masahiro Takahashi, Takahide Taguchi, Tomio Inoue and Nobuhiko Oridate

PLOS ONE, 2015, vol. 10, issue 2, 1-12

Abstract: Purpose: To evaluate the predictive and prognostic value of pretreatment metabolic tumor volume (MTV) in patients with treated by radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). Methods: We reviewed the records of 118 patients with newly diagnosed laryngeal carcinoma, who had been treated by RT or CCRT. Pretreatment positron emission tomography (PET) was performed, and MTV values were obtained by contouring margins of standardized uptake value. Clinical factors and MTV were analyzed for their association with survival. Results: Patients with residual disease showed a significantly higher MTV than those with a complete response (CR) after primary treatment. Univariate analysis showed that the patients with a high MTV had a significantly lower disease-free survival (DFS) (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0117924

DOI: 10.1371/journal.pone.0117924

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