Irritable Brain Caused by Irritable Bowel? A Nationwide Analysis for Irritable Bowel Syndrome and Risk of Bipolar Disorder

Chia-Jen Liu, Li-Yu Hu, Chiu-Mei Yeh, Yu-Wen Hu, Pan-Ming Chen, Tzeng-Ji Chen and Ti Lu

PLOS ONE, 2015, vol. 10, issue 3, 1-10

Abstract: Objective: We explored the association between IBS and the development of bipolar disorder, and the risk factors for bipolar disorders in patients with IBS. Methods: We identified patients who were newly diagnosed with IBS between 2000 and 2010 in the Taiwan National Health Insurance Research Database. We also identified a comparison matched cohort without IBS. The occurrence of new-onset bipolar disorder was evaluated in both cohorts. Results: The IBS cohort consisted of 30,796 patients and the comparison cohort consisted of 30,796 matched patients without IBS. The incidence of bipolar disorder (incidence rate ratio, 2.63, 95% confidence interval (CI) 2.10–3.31, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0118209

DOI: 10.1371/journal.pone.0118209

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