Sleep and Multisystem Biological Risk: A Population-Based Study

Judith E Carroll, Michael R Irwin, Sharon Stein Merkin and Teresa E Seeman

PLOS ONE, 2015, vol. 10, issue 2, 1-15

Abstract: Background: Short sleep and poor sleep quality are associated with risk of cardiovascular disease, diabetes, cancer, and mortality. This study examines the contribution of sleep duration and sleep quality on a multisystem biological risk index that is known to be associated with morbidity and mortality. Methods: Analyses include a population-based sample from the Midlife Development in the United States survey recruited to the Biomarker substudy. A total of 1,023 participants aged 54.5 years (SD = 11.8), 56% female and 77.6% white, were included in the analyses. A multisystem biological risk index was derived from 22 biomarkers capturing cardiovascular, immune, lipid-metabolic, glucose-metabolic, sympathetic, parasympathetic, and hypothalamic-pituitary-adrenal systems. Self-reported average sleep duration was categorized as short ( 5) sleep. Findings: Linear mixed effect models adjusting for age, gender, race, education, income, BMI, and health status were performed. As compared to normal sleepers, multisystem biological risk in both short (B(SE) = .38(.15), p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0118467

DOI: 10.1371/journal.pone.0118467

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